Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion

  title={Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion},
  author={Huabo Wang and Lokendra Sharma and Jie Lu and Paul Finch and Steven Fletcher and Edward V. Prochownik},
The c-Myc (Myc) oncoprotein is deregulated in a large proportion of diverse human cancers. Considerable effort has therefore been directed at identifying pharmacologic inhibitors as potential anti-neoplastic agents. Three such groups of small molecule inhibitors have been described. The first is comprised of so-called "direct" inhibitors, which perturb Myc's ability to form productive DNA-binding heterodimers in association with its partner, Max. The second group is comprised of indirect… CONTINUE READING
Highly Cited
This paper has 18 citations. REVIEW CITATIONS
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 10 extracted citations

AMPK-ULK1-Mediated Autophagy Confers Resistance to BET Inhibitor JQ1 in Acute Myeloid Leukemia Stem Cells.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2017
View 8 Excerpts
Highly Influenced


Publications referenced by this paper.
Showing 1-10 of 83 references

Selective inhibition of BET bromodomains

Nature • 2010
View 4 Excerpts
Highly Influenced

AMPK: a nutrient and energy sensor that maintains energy homeostasis

Nature Reviews Molecular Cell Biology • 2012
View 7 Excerpts
Highly Influenced

Myc stimulates nuclearly encoded mitochondrial genes and mitochondrial biogenesis.

Molecular and cellular biology • 2005
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…