Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion

@inproceedings{Wang2015StructurallyDC,
  title={Structurally diverse c-Myc inhibitors share a common mechanism of action involving ATP depletion},
  author={Huabo Wang and Lokendra Sharma and Jie Lu and Paul Finch and Steven Fletcher and Edward V. Prochownik},
  booktitle={Oncotarget},
  year={2015}
}
The c-Myc (Myc) oncoprotein is deregulated in a large proportion of diverse human cancers. Considerable effort has therefore been directed at identifying pharmacologic inhibitors as potential anti-neoplastic agents. Three such groups of small molecule inhibitors have been described. The first is comprised of so-called "direct" inhibitors, which perturb Myc's ability to form productive DNA-binding heterodimers in association with its partner, Max. The second group is comprised of indirect… CONTINUE READING
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