Structurally distinct hybrid polymer/lipid nanoconstructs harboring a type-I ribotoxin as cellular imaging and glioblastoma-directed therapeutic vectors.

@article{Mohamed2014StructurallyDH,
  title={Structurally distinct hybrid polymer/lipid nanoconstructs harboring a type-I ribotoxin as cellular imaging and glioblastoma-directed therapeutic vectors.},
  author={M. S. Mohamed and S. Veeranarayanan and Ankur Baliyan and A. C. Poulose and Yutaka Nagaoka and H. Minegishi and Seiki Iwai and Yasuhiro Shimane and Yasuhiko Yoshida and T. Maekawa and D. S. Kumar},
  journal={Macromolecular bioscience},
  year={2014},
  volume={14 12},
  pages={
          1696-711
        }
}
A nanoformulation composed of a ribosome inactivating protein-curcin and a hybrid solid lipid nanovector has been devised against glioblastoma. The structurally distinct nanoparticles were highly compatible to human endothelial and neuronal cells. A sturdy drug release from the particles, recorded upto 72 h, was reflected in the time-dependent toxicity. Folate-targeted nanoparticles were specifically internalized by glioma, imparting superior toxicity and curbed an aggressively proliferating in… Expand
11 Citations
A new age for biomedical applications of Ribosome Inactivating Proteins (RIPs): from bioconjugate to nanoconstructs
  • 28
...
1
2
...

References

SHOWING 1-10 OF 49 REFERENCES
Lipid-polymer hybrid nanoparticles as a new generation therapeutic delivery platform: a review.
  • Kunn Hadinoto, A. Sundaresan, Wean Sin Cheow
  • Materials Science, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2013
  • 319
AS1411 aptamer tagged PLGA‐lecithin‐PEG nanoparticles for tumor cell targeting and drug delivery
  • 117
Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.
  • 648
  • PDF
Nanoparticle-cell interactions: drug delivery implications.
  • 63
Delivering nanomedicine to solid tumors
  • 2,037
  • PDF
...
1
2
3
4
5
...