Structurally Enabled Discovery of Adenosine A2A Receptor Antagonists.

  title={Structurally Enabled Discovery of Adenosine A2A Receptor Antagonists.},
  author={Ali Jazayeri and Stephen P. Andrews and Fiona H Marshall},
  journal={Chemical reviews},
  volume={117 1},
Over the past decade there has been a revolution in the field of G protein-coupled receptor (GPCR) structural biology. Many years of innovative research from different areas have come together to fuel this significant change in the fortunes of this field, which for many years was characterized by the paucity of high-resolution structures. The determination to succeed has been in part due to the recognized importance of these proteins as drug targets, and although the pharmaceutical industry has… CONTINUE READING
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  • 2016