Structural view of cadherin-mediated cell-cell adhesion

  title={Structural view of cadherin-mediated cell-cell adhesion},
  author={J. R. Alattia and Hitomi Kurokawa and Mitsuhiko Ikura},
  journal={Cellular and Molecular Life Sciences CMLS},
Following the multiplication of biochemical, biophysical and structural studies describing cadherin molecules and their interactions, several ideas have emerged to explain the mechanisms of cadherin-mediated cell adhesion. Although different models were proposed for cadherin interactions, a consensus has come forth considering lateral dimerization of cadherins as being a central component of the cell-cell adhesion process. This review summarizes the recent development in structural studies of… CONTINUE READING

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