Structural variation in PWWP domains.

  title={Structural variation in PWWP domains.},
  author={Leanne M Slater and Mark D. Allen and Mark Bycroft},
  journal={Journal of molecular biology},
  volume={330 3},
The PWWP domain is a ubiquitous eukaryotic protein module characterised by a region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a… CONTINUE READING

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