Structural variation and (+)-amphetamine-like discriminative stimulus properties
@article{Oberlender1991StructuralVA, title={Structural variation and (+)-amphetamine-like discriminative stimulus properties}, author={Robert Oberlender and David E. Nichols}, journal={Pharmacology Biochemistry and Behavior}, year={1991}, volume={38}, pages={581-586} }
18 Citations
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These two articles may help suitable legislation to be rapidly devised to make the prohibition of DDs permanent whenever deemed necessary, as well as providing an up-to-date reference source for those engaged in the DD issue.
References
SHOWING 1-10 OF 26 REFERENCES
Structure-activity studies on amphetamine analogs using drug discrimination methodology
- Biology, ChemistryPharmacology Biochemistry and Behavior
- 1984
Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”)
- Psychology, BiologyPharmacology Biochemistry and Behavior
- 1988
Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine.
- Biology, ChemistryEuropean journal of pharmacology
- 1990
(+)-N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine as a discriminative stimulus in studies of 3,4-methylenedioxy-methamphetamine-like behavioral activity.
- Biology, ChemistryThe Journal of pharmacology and experimental therapeutics
- 1990
The results support the hypothesis that the primary behavioral activity of MDMA-like compounds is unlike that of hallucinogens and stimulants and may represent the effects of a novel drug class, given the name entactogens.
The role of dopamine in the discriminative stimulus properties of cocaine
- Biology, PsychologyNeuropharmacology
- 1980
A NEW, POTENT, CONFORMATIONALLY-RESTRICTED ANALOG OF AMPHETAMINE: 2-AMINO-1,2-DIHYDRONAPHTHALENE
- Chemistry, Biology
- 1982
Preliminary pharmacological evaluation revealed that racemic 2-ADN is approximately one-fourth as potent as (+)-amphetamine as a stimulant in mice.
Stereochemical effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain.
- Biology, ChemistryBiochemical pharmacology
- 1987
Conformational requirements for norepinephrine uptake inhibition by phenethylamines in brain synaptosomes. Effects of alpha-alkyl substitution.
- Chemistry, BiologyJournal of medicinal chemistry
- 1982
Conformational analysis of the alpha-ethyl group inalpha-ethylphenethylamine showed that this group exists in two equally populated conformations in both solvents, and it is suggested that these conformations hinder the approach of amphetamine to the brain synaptosomal NE uptake sites.
Pharmacology of 2-amino-indane hydrochloride (Su-8629): a potent non-narcotic analgesic.
- Biology, MedicineThe Journal of pharmacology and experimental therapeutics
- 1961
Su-8629 (2-amino-indane) has oral analgesic potency and a therapeutic index comparable to morphine sulfate; it is unlike morphine in that it does not depress respiration and is not antagonized by…
Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices.
- Biology, ChemistryEuropean journal of pharmacology
- 1986