Structural variability of the initiation complex of HIV-1 reverse transcription.

@article{Goldschmidt2004StructuralVO,
  title={Structural variability of the initiation complex of HIV-1 reverse transcription.},
  author={Val{\'e}rie Goldschmidt and Jean-Christophe Paillart and Micka{\"e}l Rigourd and Bernard Ehresmann and A. Aubertin and Chantal Ehresmann and Roland Marquet},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 34},
  pages={35923-31}
}
HIV-1 reverse transcription is initiated from a tRNA(3)(Lys) molecule annealed to the viral RNA at the primer binding site (PBS), but the structure of the initiation complex of reverse transcription remains controversial. Here, we performed in situ structural probing, as well as in vitro structural and functional studies, of the initiation complexes formed by highly divergent isolates (MAL and NL4.3/HXB2). Our results show that the structure of the initiation complex is not conserved. In MAL… CONTINUE READING

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