Structural variability of the external glycoprotein of simian immunodeficiency virus propagated in cell cultures.

Abstract

We examined the structural variability of the external glycoprotein (gp130) of a cloned simian immunodeficiency virus (SIV) in culture. Cloned SIVmac142 was either permanently propagated in HUT-78 cells or sequentially passaged in MT-2 cells. After 12, 24 and 60 passages of permanent or lytic cell-culture systems, virus was harvested, gp130 was isolated and… (More)

Topics

  • Presentations referencing similar topics