Structural transformation of saikosaponins by gastric juice and intestinal flora.

@article{Shimizu1985StructuralTO,
  title={Structural transformation of saikosaponins by gastric juice and intestinal flora.},
  author={Kosuke Shimizu and Sakae Amagaya and Yukio Ogihara},
  journal={Journal of pharmacobio-dynamics},
  year={1985},
  volume={8 9},
  pages={718-25}
}
Structural transformation of saikosaponin a and saikosaponin d, main components of Bupleuri Radix, were investigated using rat gastric juice (pH 1.5) and mouse intestinal flora in vitro and the excretion of saikosaponin derivatives in rat feces was also studied. Quantitative analysis of saikosaponins and their derivatives was carried out by high performance liquid chromatography. By the incubation of saikosaponins in rat gastric juice, saikosaponin a decreased with time dependently. After 3 h… CONTINUE READING

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