Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chains.

@article{Gurardel2002StructuralSO,
  title={Structural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chains.},
  author={Yann Gu{\'e}rardel and Emmanuel Maes and Elisabeth Elass and Yves Leroy and Philippe Timmerman and Gurdyal S Besra and Camille Locht and G{\'e}rard Strecker and Laurent Kremer},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 34},
  pages={30635-48}
}
Lipomannan (LM) and lipoarabinomannan (LAM) are major glycolipids present in the mycobacterial cell wall that are able to modulate the host immune response. In this study, we have undertaken the structural determination of these important modulins in Mycobacterium chelonae, a fast growing pathogenic mycobacterial species. One-dimensional and two-dimensional NMR spectra were used to demonstrate that LM and LAM from M. chelonae, designated CheLM and CheLAM, respectively, possess structures that… CONTINUE READING