Structural study of copper(I)-bleomycin

@article{Lehmann2004StructuralSO,
  title={Structural study of copper(I)-bleomycin},
  author={T. Lehmann},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2004},
  volume={9},
  pages={323-334}
}
  • T. Lehmann
  • Published 2004
  • Chemistry, Medicine
  • JBIC Journal of Biological Inorganic Chemistry
    • Previous NMR studies on Cu(I)-bleomycin have suggested that this adduct has a geometry distinct from Fe(II)BLM. The coordination chemistry of this bleomycin derivative has been investigated through the extension of the NMR data reported previously, and the use of molecular dynamics calculations. The data collected from the NMR experiments support the coordination to the metal center of the primary and secondary amines in β-aminoalanine and the pyrimidine ring. The detection in the NMR spectra… CONTINUE READING
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    References

    SHOWING 1-10 OF 51 REFERENCES
    Coordination chemistry of co(II)-bleomycin: its investigation through NMR and molecular dynamics.
    • 19
    Studies of the solution structure of the bleomycin-A2-zinc complex by means of two-dimensional NMR spectroscopy and distance geometry calculations.
    • 38
    Molecular modeling of the three-dimensional structure of Fe(II)-bleomycin: are the Co(II) and Fe(II) adducts isostructural?
    • T. Lehmann
    • Chemistry, Medicine
    • JBIC Journal of Biological Inorganic Chemistry
    • 2002
    • 17
    NMR determination of the structures of peroxycobalt(III) bleomycin and cobalt(III) bleomycin, products of the aerobic oxidation of cobalt(II) bleomycin by dioxygen.
    • 35
    The solution structure of the Ga(III)-bleomycin A2 complex resolved by NMR and molecular modeling; interaction with d(CCAGGCCTGG)
    • 3
    Copper(I) . bleomycin. A structurally unique oxidation-reduction active complex.
    • 31
    Copper(I)-bleomycin: structurally unique complex that mediates oxidative DNA strand scission.
    • 64
    Metal coordination environment and dynamics in 113cadmium bleomycin: relationship to zinc bleomycin.
    • 15
    The 1.6-Å Crystal Structure of the Copper(II)-bound Bleomycin Complexed with the Bleomycin-binding Protein from Bleomycin-producing Streptomyces verticillus *
    • 45
    • PDF
    Studies of metallobleomycins by electronic spectroscopy, electron spin resonance spectroscopy, and potentiometric titration.
    • 59