Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases.

@article{Muhammad2020StructuralSO,
  title={Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-β-lactamases.},
  author={Zeeshan Muhammad and Susann Skagseth and Marc Boomgaren and Sundus Akhter and Christopher Fr{\"o}hlich and Aya Ismael and T. Christopeit and Annette Bayer and H. Leiros},
  journal={Bioorganic & medicinal chemistry},
  year={2020},
  volume={28 15},
  pages={
          115598
        }
}
Metallo-β-lactamases (MBLs) are an emerging cause of bacterial antibiotic resistance by hydrolysing all classes of β-lactams except monobactams, and the MBLs are not inhibited by clinically available serine-β-lactamase inhibitors. Two of the most commonly encountered MBLs in clinical isolates worldwide - the New Delhi metallo-β-lactamase (NDM-1) and the Verona integron-encoded metallo-β-lactamase (VIM-2) - are included in this study. A series of several NH-1,2,3-triazoles was prepared by a… Expand
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