Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme.

  title={Structural studies of the pigeon cytosolic NADP(+)-dependent malic enzyme.},
  author={Zhiru Yang and Hailong Zhang and Hui-Chi Hung and C Kuo and Li-Chu Tsai and Hanna S. Yuan and W. -H. Chou and Gu-Gang Chang and Liang Tong},
  journal={Protein science : a publication of the Protein Society},
  volume={11 2},
Malic enzymes are widely distributed in nature, and have important biological functions. They catalyze the oxidative decarboxylation of malate to produce pyruvate and CO(2) in the presence of divalent cations (Mg(2+), Mn(2+)). Most malic enzymes have a clear selectivity for the dinucleotide cofactor, being able to use either NAD(+) or NADP(+), but not both. Structural studies of the human mitochondrial NAD(+)-dependent malic enzyme established that malic enzymes belong to a new class of… CONTINUE READING


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