Structural studies of large nucleoprotein particles, vaults

@inproceedings{Tanaka2012StructuralSO,
  title={Structural studies of large nucleoprotein particles, vaults},
  author={Hideaki Tanaka and Tomitake Tsukihara},
  booktitle={Proceedings of the Japan Academy. Series B, Physical and biological sciences},
  year={2012}
}
Vault is the largest nonicosahedral cytosolic nucleoprotein particle ever described. The widespread presence and evolutionary conservation of vaults suggest important biologic roles, although their functions have not been fully elucidated. X-ray structure of vault from rat liver was determined at 3.5 Å resolution. It exhibits an ovoid shape with a size of 40 × 40 × 67 nm(3). The cage structure of vault consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault… CONTINUE READING

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