Corpus ID: 28698084

Structural studies of Vgamma2Vdelta2 T cell phosphoantigens.

  title={Structural studies of Vgamma2Vdelta2 T cell phosphoantigens.},
  author={Y. Zhang and Y. Song and F. Yin and E. Broderick and K. Siegel and A. Goddard and E. Nieves and Ljiljana Pasa-Tolic and Y. Tanaka and H. Wang and C. T. Morita and E. Oldfield},
  journal={Chemistry & biology},
  volume={13 9},
  • Y. Zhang, Y. Song, +9 authors E. Oldfield
  • Published 2006
  • Medicine
  • Chemistry & biology
  • Human gammadelta T cells containing the Vgamma2Vdelta2 (Vgamma9Vdelta2) T cell receptor are stimulated by a broad variety of small, phosphorus-containing antigenic molecules called phosphoantigens. The structures of several species present in both Mycobacteria (TUBags1-4) and in Escherichia coli have been reported to contain a formyl-alkyl diphosphate core. Here we report the synthesis of the lead member of the series, 3-formyl-1-butyl diphosphate. This compound has low activity for gammadelta… CONTINUE READING
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