Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy

@article{Sane2015StructuralSO,
  title={Structural studies of UBXN2A and mortalin interaction and the putative role of silenced UBXN2A in preventing response to chemotherapy},
  author={S. Sane and A. Abdullah and M. Nelson and Hongmin Wang and S. Chauhan and S. S. Newton and K. Rezvani},
  journal={Cell Stress and Chaperones},
  year={2015},
  volume={21},
  pages={313-326}
}
Overexpression of the oncoprotein mortalin in cancer cells and its protein partners enables mortalin to promote multiple oncogenic signaling pathways and effectively antagonize chemotherapy-induced cell death. A UBX-domain-containing protein, UBXN2A, acts as a potential mortalin inhibitor. This current study determines whether UBXN2A effectively binds to and occupies mortalin’s binding pocket, resulting in a direct improvement in the tumor’s sensitivity to chemotherapy. Molecular modeling of… Expand
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