Structural stability of wild type and mutated alpha-keratin fragments: molecular dynamics and free energy calculations.

Abstract

The objective of this study is to investigate the influence of point mutations on the structural stability of coiled coil fragments of the human hair intermediate filament by molecular dynamics simulations and free energy calculations. Mutations in the helix termination motif of human hair keratin gene hHb6 seem to be connected to the hereditary hair… (More)

Topics

Cite this paper

@article{Danciulescu2004StructuralSO, title={Structural stability of wild type and mutated alpha-keratin fragments: molecular dynamics and free energy calculations.}, author={Cristian Danciulescu and Birgitta Nick and F Wortmann}, journal={Biomacromolecules}, year={2004}, volume={5 6}, pages={2165-75} }