Structural specificity in coiled-coil interactions.

  title={Structural specificity in coiled-coil interactions.},
  author={Gevorg Grigoryan and Amy E. Keating},
  journal={Current opinion in structural biology},
  volume={18 4},
Coiled coils have a rich history in the field of protein design and engineering. Novel structures, such as the first seven-helix coiled coil, continue to provide surprises and insights. Large-scale datasets quantifying the influence of systematic mutations on coiled-coil stability are a valuable new asset to the area. Scoring methods based on sequence and/or structure can predict interaction preferences in coiled-coil-mediated bZIP transcription factor dimerization. Experimental and… CONTINUE READING
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