Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor

  title={Structural snapshots of the mechanism and inhibition of a guanine nucleotide exchange factor},
  author={Louis Renault and Bernard Guibert and Jacqueline Cherfils},
Small GTP-binding (G) proteins are activated by GDP/GTP nucleotide exchange stimulated by guanine nucleotide exchange factors (GEFs). Nucleotide dissociation from small G protein–GEF complexes involves transient GDP-bound intermediates whose structures have never been described. In the case of Arf proteins, small G proteins that regulate membrane traffic in eukaryotic cells, such intermediates can be trapped either by the natural inhibitor brefeldin A or by charge reversal at the catalytic… CONTINUE READING
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