Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues.

@article{Matsumoto2001StructuralSO,
  title={Structural similarity of ghrelin derivatives to peptidyl growth hormone secretagogues.},
  author={Masaki Matsumoto and Yasuo Kitajima and Taisuke Iwanami and Yasuhiro Hayashi and Sachiyo Tanaka and Yoshiharu Minamitake and Hiroshi Hosoda and Masaki Kojima and Hisayuki Matsuo and Kenji Kangawa},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={284 3},
  pages={655-9}
}
Ghrelin is a 28-amino acid residue endogenous growth hormone secretagogue. Intensive investigations revealed that the N-terminus tetrapeptide, having octanoyl group at Ser(3), is the minimum active core. In this study, we further explored the structure-function relationships of the active N-terminus portion of ghrelin using a Ca(2+) mobilization assay. The smallest and most potent ghrelin derivative we have found so far is 5-aminopentanoyl-Ser(Octyl)-Phe-Leu-aminoethylamide, showing comparable… CONTINUE READING

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