Structural similarity between the bone marrow extracellular matrix protein and neurokinin 1 could be the limiting factor in the hematopoietic effects of substance P.

@article{Rameshwar2002StructuralSB,
  title={Structural similarity between the bone marrow extracellular matrix protein and neurokinin 1 could be the limiting factor in the hematopoietic effects of substance P.},
  author={Pranela Rameshwar and Pedro Gasc{\'o}n and Persis S Bandari and Deval D Joshi and Annemarie Fernandes and Anju M. Dang},
  journal={Canadian journal of physiology and pharmacology},
  year={2002},
  volume={80 5},
  pages={475-81}
}
In the adult bone marrow (BM), immune cells are replenished through the process of definitive hematopoiesis, which is regulated by a complex process of cellular and humoral interactions. The latter include substance P (SP), a neurotransmitter that is produced by neural and nonneural cells. Neurokinin-1 (NK-1), the high-affinity SP receptor, shares structural similarity with fibronectin, a component of the BM extracellular matrix proteins. This study examines how such similarity could alter the… CONTINUE READING