Structural significance of azaheterocyclic amines related to Parkinson's disease for dopamine transporter.

@article{Matsubara1998StructuralSO,
  title={Structural significance of azaheterocyclic amines related to Parkinson's disease for dopamine transporter.},
  author={Kazuo Matsubara and Toshiya Senda and Takashi Uezono and Setsu Fukushima and Shunsaku Ohta and Kazuo Igarashi and Makato Naoi and Yuko Yamashita and Ko-ichi Ohtaki and Nobuaki Hayase and Shigeto Akutsu and Kiyoshi Kimura},
  journal={European journal of pharmacology},
  year={1998},
  volume={348 1},
  pages={77-84}
}
We have evaluated the neuronal uptake of 12 neutral and quaternary azaheterocyclic amines that are possible candidates for idiopathic Parkinson's disease via dopamine transporter of striatal synaptosomes. The double-reciprocal plots for dopamine transporter obtained from Wistar rat and C57BL/6 mouse synaptosomes with N-methyl-4-phenylpyridinium cation (MPP+) as a substrate were identical to each other. Neutral beta-carbolines and tetrahydroisoquinolines were unfavorable substrates for dopamine… CONTINUE READING