Structural role of Sfi1p–centrin filaments in budding yeast spindle pole body duplication

@article{Li2006StructuralRO,
  title={Structural role of Sfi1p–centrin filaments in budding yeast spindle pole body duplication},
  author={Suo Ping Li and Alan M. Sandercock and Paul T. Conduit and Carol V Robinson and Roger L Williams and John V. Kilmartin},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={173},
  pages={867 - 877}
}
Centrins are calmodulin-like proteins present in centrosomes and yeast spindle pole bodies (SPBs) and have essential functions in their duplication. The Saccharomyces cerevisiae centrin, Cdc31p, binds Sfi1p on multiple conserved repeats; both proteins localize to the SPB half-bridge, where the new SPB is assembled. The crystal structures of Sfi1p-centrin complexes containing several repeats show Sfi1p as an alpha helix with centrins wrapped around each repeat and similar centrin-centrin… CONTINUE READING

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Cytology of the yeast cell cycle

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