Structural requirements of taxoids for nitric oxide and tumor necrosis factor production by murine macrophages.

@article{Kirikae1996StructuralRO,
  title={Structural requirements of taxoids for nitric oxide and tumor necrosis factor production by murine macrophages.},
  author={Teruo Kirikae and Iwao Ojima and Fumiko Kirikae and Zheng Ma and Scott D. Kuduk and J. L. Slater and Cindy Takeuchi and P Y Bounaud and Masayasu Nakano},
  journal={Biochemical and biophysical research communications},
  year={1996},
  volume={227 1},
  pages={227-35}
}
Taxol (paclitaxel), a microtubule stabilizer with antitumor activity, mimics the actions of lipopolysaccharide (LPS) on murine macrophages (M phi). In the present study, a variety of synthetic analogs of paclitaxel were examined for their potencies to induce nitric oxide (NO) and tumor necrosis factor (TNF) production by peritoneal M phi from LPS-responsive C3H/HeN, and LPS-hyporesponsive C3H/HeJ mice, and by M phi-like LPS-responsive J774.1 and its mutant LPS-hyporesponsive J7.DEF3 cells. In… CONTINUE READING