Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells.

@article{Mastuda2002StructuralRO,
  title={Structural requirements of flavonoids for inhibition of antigen-Induced degranulation, TNF-alpha and IL-4 production from RBL-2H3 cells.},
  author={Hisashi Mastuda and Toshio Morikawa and Kazuho Ueda and Hiromi Managi and Masayuki Yoshikawa},
  journal={Bioorganic & medicinal chemistry},
  year={2002},
  volume={10 10},
  pages={3123-8}
}
To clarify the structure-activity relationships of flavonoids for antiallergic activity, the inhibitory effects of various flavonoids on the release of beta-hexosaminidase, as a marker of degranulation of RBL-2H3 cells, were examined. Among them, luteolin (IC(50)=3.0 microM), diosmetin (2.1 microM), and fisetin (3.0 microM) were found to show potent inhibitory activity, and the results suggested the following structural requirements of flavonoids: (1) the 2-3 double bond of flavones and… CONTINUE READING
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