Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity.

@article{Matsuda2002StructuralRO,
  title={Structural requirements of flavonoids and related compounds for aldose reductase inhibitory activity.},
  author={H. Matsuda and T. Morikawa and I. Toguchida and M. Yoshikawa},
  journal={Chemical \& pharmaceutical bulletin},
  year={2002},
  volume={50 6},
  pages={
          788-95
        }
}
The methanolic extracts of several natural medicines and medicinal foodstuffs were found to show an inhibitory effect on rat lens aldose reductase. In most cases, flavonoids were isolated as the active constituents by bioassay-guided separation, and among them, quercitrin (IC(50)=0.15 microM), guaijaverin (0.18 microM), and desmanthin-1 (0.082 microM) exhibited potent inhibitory activity. Desmanthin-1 showed the most potent activity, which was equivalent to that of a commercial synthetic aldose… Expand
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