Structural requirements of analogues of polyamines for migration and growth of IEC-6 cells.

@article{McCormack1995StructuralRO,
  title={Structural requirements of analogues of polyamines for migration and growth of IEC-6 cells.},
  author={Shirley A. McCormack and Barbara J. Zimmerman and Mervyn Israel and Patrick M Blanner and Leonard R. Johnson},
  journal={Molecular pharmacology},
  year={1995},
  volume={48 4},
  pages={724-9}
}
Healing of gastrointestinal mucosal lesions occurs through two processes: an early one involving cell migration and a later one in which cell division replaces lost cells. Both processes require the presence of polyamines, but the mechanism of action of these compounds is unknown. In the present study, we examined the ability of analogues of spermidine and spermine to support migration and growth of IEC-6 cells that have been grown in alpha-difluoromethylornithine to inhibit polyamines. All… CONTINUE READING