Structural requirements of Dictyostelium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyostelium cells and anti-proliferative activity in K562 human leukemic cells.

@article{Gokan2005StructuralRO,
  title={Structural requirements of Dictyostelium differentiation-inducing factors for their stalk-cell-inducing activity in Dictyostelium cells and anti-proliferative activity in K562 human leukemic cells.},
  author={Naomi Gokan and Haruhisa Kikuchi and Kyotaro Nakamura and Yoshiteru Oshima and Kohei Hosaka and Yuzuru Kubohara},
  journal={Biochemical pharmacology},
  year={2005},
  volume={70 5},
  pages={
          676-85
        }
}
The differentiation-inducing factor-1 (DIF-1) is a lipophilic signal molecule (chlorinated alkylphenone) that induces stalk-cell differentiation in the cellular slime mould Dictyostelium discoideum. It has also been shown that DIF-1 and its derivative (DIF-3) suppress cell growth in mammalian tumor cells. In the present study, in order to assess the chemical structure-effect relationship of DIF derivatives and to develop useful agents for the study of both Dictyostelium development and cancer… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 13 CITATIONS

A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1 Activity and Breast Cancer Cell Proliferation

  • International journal of cancer and clinical research
  • 2015
VIEW 10 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

The Dictyostelium prestalk inducer DIF-1 directs phosphorylation of a bZIP transcription factor.

  • The International journal of developmental biology
  • 2013
VIEW 3 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

Similar Papers

Loading similar papers…