Structural requirements for the inhibition of human monocyte carboxylesterase by organophosphorus compounds.

  title={Structural requirements for the inhibition of human monocyte carboxylesterase by organophosphorus compounds.},
  author={Ali M. Saboori and David Michael Lang and David S. Newcombe},
  journal={Chemico-biological interactions},
  volume={80 3},

The mammalian carboxylesterases: from molecules to functions.

A comparison of the nucleotide and amino acid sequence of the mammalian carboxylesterases shows that all forms expressed in the rat can be assigned to one of three gene subfamilies with structural identities of more than 70% within each subfamily.

In vitro inhibition of lysine decarboxylase activity by organophosphate esters.

Tissue Carboxylesterases and Chlorpyrifos Toxicity in the Developing Rat

In vitro and in vivo evidence is presented demonstrating that the carboxylesterases are critical for explaining the age-related sensitivity of chlorpyrifos and proposing that the detoxification potential of these enzymes is multifaceted.

Rapid in vitro metabolism of the flame retardant triphenyl phosphate and effects on cytotoxicity and mRNA expression in chicken embryonic hepatocytes.

First reported evidence that across 27 toxicologically relevant genes, DPHP altered more transcripts than its precursor, and that TPHP is also metabolized via a hydroxylation pathway in CEH is reported.

Biology of Monocyte-Specific Esterase

A more thorough understanding of the in vivo function of function of this truly unique enzyme should be helped by characterizing the signals anti signal transduction mechanisms which lead to MSE expression.

Organophosphorous Pesticides Metabolite Reduces Human T CD8 Homeostasis and Proliferation by Inducing Cellular Death

DEDTP showed higher toxicity and cytostaticity in TCD8 cells than in T CD4 lymphocytes, relevant in exposed individuals as their ability to deal with viral infections and cancer cells could be limited by exposure to OP pesticides.

Pharmacokinetics and molecular detoxication.

Several important metabolic detoxication enzymes are presented, including the mammalian microsomal cytochrome P450 and flavin-containing monooxygenases as well as carboxylesterases and glucuronosyltransferases, to provide insight into the processes of chemical detoxication in mammalian tissue and blood.



Inhibition of monocyte esterase activity by organophosphate insecticides.

The inhibition of this enzyme by airborne contaminants, however, may interfere with the proper functioning of the Hemalog D, and this effect in vivo has not yet been shown, nor is it clear what the implications of such an effect would be.

The relevance of α‐naphthyl acetate esterases to various monocyte functions

Investigations show that monocyte specific αNA esterases are involved in the spontaneous cytotoxicity of monocytes toward tumour cells.

Human monocyte carboxylesterase. Purification and kinetics.

Monocyte esterase deficiency in malignant neoplasia.

It is suggested that the reason for the increased prevalence of the anomaly in these disorders might be that the diminution of esterase activity has a role in their development.