Structural requirements for the inhibition of human monocyte carboxylesterase by organophosphorus compounds.

@article{Saboori1991StructuralRF,
  title={Structural requirements for the inhibition of human monocyte carboxylesterase by organophosphorus compounds.},
  author={A. M. Saboori and D. Lang and D. Newcombe},
  journal={Chemico-biological interactions},
  year={1991},
  volume={80 3},
  pages={
          327-38
        }
}
  • A. M. Saboori, D. Lang, D. Newcombe
  • Published 1991
  • Chemistry, Medicine
  • Chemico-biological interactions
    • Human blood monocyte carboxylesterase (CBE) is inhibited by a variety of organophosphorus compounds including arylphosphates and arylphosphites and some alkylphosphites. Triphenyl phosphate and triphenyl phosphite with Ki values of 8 x 10(-9) M and 4.8 x 10(-8) M, respectively, are the most potent inhibitors of this enzyme evaluated by this study. The arylphosphates vary in their capacity to inhibit carboxylesterase activity. Diphenyl phosphate with its strong negative charge is not a potent… CONTINUE READING
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