Structural requirements for the inhibition of human monocyte carboxylesterase by organophosphorus compounds.

@article{Saboori1991StructuralRF,
  title={Structural requirements for the inhibition of human monocyte carboxylesterase by organophosphorus compounds.},
  author={Ali M. Saboori and David Michael Lang and David S. Newcombe},
  journal={Chemico-biological interactions},
  year={1991},
  volume={80 3},
  pages={
          327-38
        }
}

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In vitro and in vivo evidence is presented demonstrating that the carboxylesterases are critical for explaining the age-related sensitivity of chlorpyrifos and proposing that the detoxification potential of these enzymes is multifaceted.

Rapid in vitro metabolism of the flame retardant triphenyl phosphate and effects on cytotoxicity and mRNA expression in chicken embryonic hepatocytes.

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A more thorough understanding of the in vivo function of function of this truly unique enzyme should be helped by characterizing the signals anti signal transduction mechanisms which lead to MSE expression.

Organophosphorous Pesticides Metabolite Reduces Human T CD8 Homeostasis and Proliferation by Inducing Cellular Death

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Pharmacokinetics and molecular detoxication.

Several important metabolic detoxication enzymes are presented, including the mammalian microsomal cytochrome P450 and flavin-containing monooxygenases as well as carboxylesterases and glucuronosyltransferases, to provide insight into the processes of chemical detoxication in mammalian tissue and blood.
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