Structural requirements for the binding of benzodiazepines to their peripheral-type sites.

@article{Wang1984StructuralRF,
  title={Structural requirements for the binding of benzodiazepines to their peripheral-type sites.},
  author={Jignfeng Wang and Takanobu Taniguchi and Sydney Spector},
  journal={Molecular pharmacology},
  year={1984},
  volume={25 3},
  pages={349-51}
}
The DS19 Friend erythroleukemia cells possess peripheral-type benzodiazepine recognition sites that are similar to those characterized in other tissues and cells. These sites recognize only specific and well-defined ligand structures. In order for the benzodiazepines to bind to these sites, an alkyl group of 3 carbons or less is required at position 1, together with a carbonyl group at position 2. In addition, the binding affinity is enhanced by 4'-halogen or 4'-methoxy substituents, and by 7… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…