Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides

@article{LeindersZufall2009StructuralRF,
  title={Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides},
  author={Trese Leinders-Zufall and Tomohiro Ishii and Peter Mombaerts and Frank Zufall and Thomas Boehm},
  journal={Nature Neuroscience},
  year={2009},
  volume={12},
  pages={1551-1558}
}
In addition to their role in the immune response, peptide ligands of major histocompatibility complex (MHC) molecules function as olfactory cues for subsets of vomeronasal sensory neurons (VSNs) in the mammalian nose. How MHC peptide diversity is recognized and encoded by these cells is unclear. We found that mouse VSNs expressing the vomeronasal receptor gene V2r1b (also known as Vmn2r26) detected MHC peptides at subpicomolar concentrations and exhibited combinatorial activation with… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Similar Papers

Loading similar papers…