Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists.

@article{More2003StructuralRF,
  title={Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists.},
  author={Julia C A More and Helen M Troop and Nigel P Dolman and David E. Jane},
  journal={British journal of pharmacology},
  year={2003},
  volume={138 6},
  pages={1093-100}
}
1. The natural product willardiine is an AMPA receptor agonist. We have examined the structural changes required to convert willardiine into an antagonist at AMPA and kainate receptors. Structure-activity analysis has been carried out to discover the structural features required to increase the potency and/or selectivity of the antagonists at AMPA or kainate receptors. 2. Reduction of the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) has been used to investigate AMPA… CONTINUE READING

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