Structural requirements for intracellular targeting of SP-C proprotein.

  title={Structural requirements for intracellular targeting of SP-C proprotein.},
  author={Scott J Russo and Wenjing Wang and Catherine A Lomax and Michael F. Beers},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  volume={277 5},
Rat surfactant protein (SP) C is synthesized as a 194-amino acid proprotein that is proteolytically processed to a 35-amino acid mature form in subcellular compartments distal to the medial Golgi compartment. To identify domains of SP-C proprotein (proSP-C) necessary for endoplasmic reticulum translocation and for targeting to cytosolic processing… CONTINUE READING