Structural requirements for drug binding to site II on human serum albumin.

@article{Wanwimolruk1983StructuralRF,
  title={Structural requirements for drug binding to site II on human serum albumin.},
  author={Sompon Wanwimolruk and Donald Birkett and Peter M Brooks},
  journal={Molecular pharmacology},
  year={1983},
  volume={24 3},
  pages={458-63}
}
Structure-activity relationships for binding at site II on human serum albumin have been investigated using drugs, fatty acids, and aliphatic amines with chain lengths C-3 to C-18. A negative charge is not required for binding provided a strongly electronegative center is present. For example, diazepam, a basic drug that exists mainly in the un-ionized form at neutral pH, also binds with high affinity to site II. However, aliphatic amines (pKa values 10-11) with chain lengths C-3 to C-12 did… CONTINUE READING

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