Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF.

@article{Claffey1995StructuralRF,
  title={Structural requirements for dimerization, glycosylation, secretion, and biological function of VPF/VEGF.},
  author={Kevin P. Claffey and Donald R. Senger and Bruce M. Spiegelman},
  journal={Biochimica et biophysica acta},
  year={1995},
  volume={1246 1},
  pages={1-9}
}
Vascular permeability factor (VPF) also known as vascular endothelial growth factor (VEGF), is a dimeric protein that affects endothelial cell (EC) and vascular functions including enhancement of microvascular permeability and stimulation of EC growth. To investigate the structural features of VPF/VEGF necessary for efficient dimerization, secretion, and biological activities, we employed site-directed mutagenesis with a Cos-1 cell expression system. Several cysteine residues essential for VPF… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 31 extracted citations

Targeting Splicing in Prostate Cancer

International journal of molecular sciences • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…