Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin.

Abstract

Calmodulin modulation of ion channels has emerged as a prominent theme in biology. The sensitivity of KCNQ1-5 K+ channels to modulation by Ca2+/calmodulin (CaM) was studied using patch-clamp, Ca2+ imaging, and biochemical and pharmacological approaches. Coexpression of CaM in Chinese hamster ovary (CHO) cells strongly reduced currents of KCNQ2, KCNQ4, and… (More)

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@article{Gamper2005StructuralRF, title={Structural requirements for differential sensitivity of KCNQ K+ channels to modulation by Ca2+/calmodulin.}, author={Nikita Gamper and Yang Li and Mark S. Shapiro}, journal={Molecular biology of the cell}, year={2005}, volume={16 8}, pages={3538-51} }