Structural requirements for cannabinoid-induced antinociceptive activity in mice.

@article{Martin1985StructuralRF,
  title={Structural requirements for cannabinoid-induced antinociceptive activity in mice.},
  author={Billy R. Martin},
  journal={Life sciences},
  year={1985},
  volume={36 16},
  pages={
          1523-30
        }
}
The antinociceptive activity of delta 9-THC was found to be 45 times greater after i.v. (ED50 = 1.0 mg/kg) than after s.c. administration while its ability to depress spontaneous activity was increased only 8 fold. Route of administration had less of an impact on the antinociceptive potency of hydroxylated metabolites and analogs of delta 9-THC. The structural requirements for antinociception and depression of spontaneous activity were found to be similar. Both routes of administration and… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…