Structural requirements for bisphosphonate binding on hydroxyapatite: NMR study of bisphosphonate partial esters.

  title={Structural requirements for bisphosphonate binding on hydroxyapatite: NMR study of bisphosphonate partial esters.},
  author={Elina Puljula and Petri A. Turhanen and Jouko Veps{\"a}l{\"a}inen and Maelle Monteil and Marc Lecouvey and Janne Weisell},
  journal={ACS medicinal chemistry letters},
  volume={6 4},
Eighteen different bisphosphonates, including four clinically used bisphosphonate acids and their phosphoesters, were studied to evaluate how the bisphosphonate structure affects binding to bone. Bisphosphonates with weak bone affinity, such as clodronate, could not bind to hydroxyapatite after the addition of one ester group. Medronate retained its ability to bind after the addition of one ester group, and hydroxy-bisphosphonates could bind even after the addition of two ester groups. Thus… 

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