Structural requirement of highly-conserved residues in globins.

@article{Ota1997StructuralRO,
  title={Structural requirement of highly-conserved residues in globins.},
  author={Motonori Ota and Yasuhiro Isogai and K. I. Nishikawa},
  journal={FEBS letters},
  year={1997},
  volume={415 2},
  pages={
          129-33
        }
}
Globins have remarkable sequence diversity, and yet maintain a common fold. In spite of the diversity, there are highly-conserved residues at several sites. The conserved residues were examined in terms of the structural stability, by employing the pseudo-energy functions of the structure/sequence compatibility method. The fitness of each residue type to the structural environment was evaluated at seven highly-conserved sites: the Leu (at the B10 site), Phe (CD1), and Leu (F4) residues were… CONTINUE READING

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