Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins.

@article{Fujita2010StructuralRO,
  title={Structural remodeling of GPI anchors during biosynthesis and after attachment to proteins.},
  author={Morihisa Fujita and Taroh Kinoshita},
  journal={FEBS letters},
  year={2010},
  volume={584 9},
  pages={1670-7}
}
Glycosylphosphatidylinositol (GPI) anchoring of proteins is a conserved post-translational modification in eukaryotes. In mammalian cells, approximately 150 proteins on the plasma membrane are attached to the cell surface by GPI anchors, which confer specific properties on proteins, such as association with membrane microdomains. The structures of lipid and glycan moieties on GPI anchors are remodeled during biosynthesis and after attachment to proteins. The remodeling processes are critical… CONTINUE READING