Structural relationships in the adenylate kinase family.

  title={Structural relationships in the adenylate kinase family.},
  author={Georg E. Schulz and Emile Schiltz and Alfredo G. Tomasselli and Ronald M Frank and Martin Brune and Alfred Wittinghofer and R. Heiner Schirmer},
  journal={European journal of biochemistry},
  volume={161 1},
The sequences of five distantly related adenylate kinases have been aligned. The local conservation of amino acids is discussed in the light of the known three-dimensional structure of one of the enzymes, the cytosolic isoenzyme 1 (AK1) from porcine muscle. The similarity profile outlines clearly the active site in the cleft of the spatial structure of AK1… CONTINUE READING