Structural relationships in the OmpR family of winged-helix transcription factors.

  title={Structural relationships in the OmpR family of winged-helix transcription factors.},
  author={Erik Martinez-Hackert and Ann M Stock},
  journal={Journal of molecular biology},
  volume={269 3},
OmpR, a protein that regulates expression of outer membrane porin proteins in enteric bacteria, belongs to a large family of transcription factors. These transcription factors bind DNA and interact productively with RNA polymerase to activate transcription. The two functions, DNA-binding and transcriptional activation, have been localized within the 100 amino acid DNA-binding domain that characterizes members of the OmpR family. Both DNA binding and transcriptional activation by OmpR related… CONTINUE READING
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