Structural rearrangements on HIV-1 Tat (32-72) TAR complex formation.

@article{Metzger1996StructuralRO,
  title={Structural rearrangements on HIV-1 Tat (32-72) TAR complex formation.},
  author={Andreas Metzger and Thomas Schindler and Dieter Willbold and Madelyne Kraft and Clemens Steegborn and Armin Volkmann and Rainer W. Frank and PaulJ. Rosch},
  journal={FEBS letters},
  year={1996},
  volume={384 3},
  pages={
          255-9
        }
}
Expression of the early genes of the human immunodeficiency virus type-I (HIV-1) genome is under the control of a trans-activator (Tat) protein. HIV-1 Tat action requires binding to TAR (trans-activation responsive element), an RNA sequence located at the 5'-end of all lentiviral mRNAs. We used various spectroscopic methods to investigate conformational changes on HIV-1 TAR binding to the HIV-1 (32-72) Tat peptide BP1. It comprises the RNA binding region and binds specifically to TAR. We… CONTINUE READING
BETA

From This Paper

Figures, tables, and topics from this paper.

References

Publications referenced by this paper.

LeGrow, A.U

  • M. G. Cordingley, R. L. LaFemina, +4 authors T. M. Nguyen
  • Metzger et al./FEBS Letters
  • 1996

Similar Papers

Loading similar papers…