Structural rearrangements in the membrane penetration protein of a non-enveloped virus

Abstract

Non-enveloped virus particles (those that lack a lipid-bilayer membrane) must breach the membrane of a target host cell to gain access to its cytoplasm. So far, the molecular mechanism of this membrane penetration step has resisted structural analysis. The spike protein VP4 is a principal component in the entry apparatus of rotavirus, a non-enveloped virus… (More)
DOI: 10.1038/nature02836

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