Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3.

@article{Stjernschantz2008StructuralRO,
  title={Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3.},
  author={Eva Stjernschantz and Barbara M. A. van Vugt-Lussenburg and Alois Bonifacio and Stephanie B. A. de Beer and Gert van der Zwan and Cees Gooijer and Jan N. M. Commandeur and Nico P E Vermeulen and Chris Oostenbrink},
  journal={Proteins},
  year={2008},
  volume={71 1},
  pages={336-52}
}
Three newly discovered drug metabolizing mutants of cytochrome P450 BM3 (van Vugt-Lussenburg et al., Identification of critical residues in novel drug metabolizing mutants of Cytochrome P450 BM3 using random mutagenesis, J Med Chem 2007;50:455-461) have been studied at an atomistic level to provide structural explanations for a number of their characteristics. In this study, computational methods are combined with experimental techniques. Molecular dynamics simulations, resonance Raman and UV… CONTINUE READING

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