Structural properties of dibenzosuberanylpiperazine derivatives for efficient reversal of chloroquine resistance in Plasmodium chabaudi.

@article{Osa2003StructuralPO,
  title={Structural properties of dibenzosuberanylpiperazine derivatives for efficient reversal of chloroquine resistance in Plasmodium chabaudi.},
  author={Y. Osa and Seiki Kobayashi and Yoko Sato and Y. Suzuki and K. Takino and T. Takeuchi and Y. Miyata and M. Sakaguchi and H. Takayanagi},
  journal={Journal of medicinal chemistry},
  year={2003},
  volume={46 10},
  pages={
          1948-56
        }
}
For the purpose of developing chemosensitizers to reverse chloroquine (CQ) resistance in Plasmodium chabaudi in vivo, dibenzosuberanylpiperazine (1-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-yl)piperazine) (DSP) and its piperazin-1-yl derivatives were synthesized systematically. DSP hydrochloride (3) was obtained from the reaction of dibenzosuberanyl chloride with piperazine in the presence of 1,8-diazabicyclo[5,4,0]-7-undecene (DBU). To understand the relationship between the substituent… Expand
29 Citations
Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives
Antiprotozoal Agents: An Overview
...
1
2
3
...