Structural profiles of human miRNA families from pairwise clustering

  title={Structural profiles of human miRNA families from pairwise clustering},
  author={Bogumił Kaczkowski and Elfar Torarinsson and Kristin Reiche and Jakob Hull Havgaard and Peter F. Stadler and Jan Gorodkin},
  volume={25 3},
UNLABELLED MicroRNAs (miRNAs) are a group of small, approximately 21 nt long, riboregulators inhibiting gene expression at a post-transcriptional level. Their most distinctive structural feature is the foldback hairpin of their precursor pre-miRNAs. Even though each pre-miRNA deposited in miRBase has its secondary structure already predicted, little is known about the patterns of structural conservation among pre-miRNAs. We address this issue by clustering the human pre-miRNA sequences based on… 

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