Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch

  title={Structural principles of nucleoside selectivity in a 2′-deoxyguanosine riboswitch},
  author={Olga Pikovskaya and Anna Polonskaia and Dinshaw J. Patel and Alexander Serganov},
  booktitle={Nature chemical biology},
Purine riboswitches have an essential role in genetic regulation of bacterial metabolism. This family includes the 2'-deoxyguanosine (dG) riboswitch, which is involved in feedback control of deoxyguanosine biosynthesis. To understand the principles that define dG selectivity, we determined crystal structures of the natural Mesoplasma florum riboswitch bound to cognate dG as well as to noncognate guanosine, deoxyguanosine monophosphate and guanosine monophosphate. Comparison with related purine… CONTINUE READING
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