Structural principles of α/β barrel proteins: The packing of the interior of the sheet

@inproceedings{Lesk1989StructuralPO,
  title={Structural principles of α/β barrel proteins: The packing of the interior of the sheet},
  author={Arthur M. Lesk and Carl-Ivar Br{\"a}nd{\'e}n and Cyrus Chothia},
  year={1989}
}
α/β barrel structures very similar to that first observed in triose phosphate isomerase are now known to occur in 14 enzymes. To understand the origin of this fold, we analyzed in three of these proteins the geometry of the eight-stranded β-sheets and the packing of the residues at the center of the barrel. The Packingin thisregion is seen in its simplest form in glycolate oxidase. It consists of 12 residues arranged in three layers. Each layer contains four side chains. The packing of RubisCO… CONTINUE READING

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