Structural polymorphism of the actin-espin system: a prototypical system of filaments and linkers in stereocilia.

@article{Purdy2007StructuralPO,
  title={Structural polymorphism of the actin-espin system: a prototypical system of filaments and linkers in stereocilia.},
  author={Kirstin R. Purdy and James Richard Bartles and Gerard C. L. Wong},
  journal={Physical review letters},
  year={2007},
  volume={98 5},
  pages={
          058105
        }
}
  • Kirstin R. Purdy, James Richard Bartles, Gerard C. L. Wong
  • Published in Physical review letters 2007
  • Physics, Medicine
  • We examine the interaction between cytoskeletal F-actin and espin 3A, a prototypical actin bundling protein found in sensory cell microvilli, including ear cell stereocilia. Espin induces twist distortions in F-actin as well as facilitates bundle formation. Mutations in one of the two F-actin binding sites of espin, which have been implicated in deafness, can tune espin-actin interactions and radically transform the system's phase behavior. These results are compared to recent theoretical work… CONTINUE READING

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